COVID-19

NasalCare® Products for Prevention of COVID-19

Your nose is the body's primary organ of smell and also functions as part of main respiratory system. It’s the entrance of upper respiratory tract. There are two major parts for your nose: nasal passages and nasal cavity.
Nasal passages: lined with mucous membranes and tiny hairs (cilia) that help to filter the air. 
Nasal cavity: composed primarily of frontal, maxillary, sphenoid and ethmoid sinuses, responsible for assistance to breathing, smelling, immune system. It’s also the entrance of lower respiratory tract through lungs.

What We Have Known About COVID-19

COVID-19 is a new respiratory infection disease caused by a novel virus SARS-CoV-2. 
Early symptoms: dry cough, sore throat, loss of taste or smell, aches and pains, or asymptom.
Initial spread of the virus: [1,3] 
1. Mainly spreading through nasal passages.
2. Contacting by direct or indirect. 
3. Droplet’s spraying in short range.
4. Aerosol /airborne spreading in long-range. 
Early Incubation of the virus:Recent findings demonstrated [3] that the nasal cavity is a docking site of initial incubation infection ( 3~7 days). There may be showed as asymptom during this period.
Treatments: no vaccines or specific anti-virus medicines for COVID-19 nowadays. 
Effective prevention of the spread: 1. Washing and clean your hands often.
2. Maintaining a safely social distance.
3. Not touching your eyes, nose or mouth. 
4. Wearing face masks. 

The Role of Nasal in COVID-19

1. A recent review by science group of US and Switzerland revealed that the role of the nasal and para-nasal sinus cavities is increasingly recognized for COVID-19 symptomatology and transmission. [4] 
2. The nasal sinus is first docking location of virus SARS-CoV-2 through nasal passageway of the virus droplets in the air. The virus’s entry is highly expressed in nasal epithelial cells by the enzyme ACE2 for initial infection. The virus is exceedingly infections in the nasal cavity through its replication and accumulation in the epithelial cells, and consequently, released and transmitted to the lungs by the lower respiratory tract. [3] 
3. The initial infected sinonasal cavity may be an entrance of SARS-CoV-2 transmitted to the disease COVID-19. 
4. Efficiently washing and cleaning sinonasal cavity would be a new approach in effect for preventing from COVID-19 and reducing its spreads.

Why NasalCare® Products Can Help PreventCOVID-19

TWC TechWorld has recently developed new NasalCare® Starter Kit for daily washing and cleaning your sinonasal to provide a significant approach for preventing from the diseases caused by the virus and protecting your sinonasal.
The new NasalCare® Starter Kit is composed of two parts: the irrigator and the patented nasal rinse mix. 
The unique-designed irrigator is a nasal-sinus irrigation system with an anti-backflow technology. It can overcome the problems of back wash contamination and the associated risk of sinus re-infection, growing concerns in the medical community; the nasal rinse mix is consist of various positive ions such as Na+, K+, Sr+2, Mn+2, Al+3, Ba+2, Fe+2, Cu+2, Ag+, and Zn+2, as well as negative ions Cl-, HCO3-, CO3-2, SO3-2, SO4-2, H2BO3-, Br-, and PO4-3 . The positive ions are usually functioned to inhibit or kill bacteria and viruses, and assorted with negative ions to form a relatively stable alkali-buffers that help easily-washing out, and protecting nasal epithelial cells. Higher pH values and the alkali-buffers also assist to inhibit bacteria and viruses.[5,6] Further, the residues of nasal rinse mix in nasal cavity after washing potentially assist to raise the immune system of sinonasal against viruses and bacteria and protect the functions of nasal epithelial cells. [6] 
The functions and advantages of TWC new NasalCare® Starter Kit are summarized as follows:
1. It is easily used for washing nasal passages and nasal cavity safely and deeply. 
2. The irrigator is unique-designed with an anti-backflow technology. 
3. The washing nasal rinse mix is patented and has obvious advantages in contrast to saline.
4. It is clinically demonstrated to efficiently wash out influenza viruses, bacteria, and allergen from the nasal cavity and protect the functions of sinonasal. [6-12] 
5. The solution residue of the nasal rinse mix would potentially help enhancing the nasal immune.
About TechWorld Corporation, Inc.
TechWorld Corporation, Inc. (“the TWC”) is an enterprise engaged in the research, development, manufacture, and marketing of medical devices, OTC drugs, nutraceuticals, health beverages, and food supplements. The TWC has developed and marketed the products in treating respiratory diseases such as NasalCare® Nasal Cleanse Kit, NasalCare® Nasal Irrigator Cleansed out Flu Viruses, Nasal Rinse Starter Kit, Nasal Rinse Starter Kit for kids. (www.techworldcorp.net) 
For more information, please contact:
At the Company:
Email: info@twcpharm.com
Phone: 888-205-8275
References
[1] Nelson A. Z.; et all: Embedded droplet printing in yield-stress fluids. PNAS, 2020, 117 (11), 5671-5679.
[2] Korber, B.; Fischer, W., et all: Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2, bixRxiv, May 5, 2020.
[3] Sungnak, W.; et al: SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nature Medicine, April 23, 2020.
[4] Gengler, I.; et al: Sinonasal pathophysiology of SARS-CoV-2 and COVID-19: A systematic review of the current evidence. Laryngoscope Investigative Otolaryngology, 2020, April 3, 1–6.
[5] Pinon, A.; and Vialette, M.: Survival of viruses in water, Intervirology, 2018, 61, 214-222.
[6] Ramalingam, S.; et al: A pilot, open labelled, randomized controlled trial of hypertonic salinenasal irrigation and gargling for the common cold. Scientific Reports, 9, January, 2019. 
[7] Douglas RG Jr, Cate TR, Gerone JP, Couch RB. Quantitative rhinovirus shedding patterns in volunteers. Am Rev Respir Dis. 1966; 94:159-167.
[8] Ivo Šlapak, MD; Jana Skoupá, MD; Petr Strnad, MD; Pavel Horník, MD. Efficacy of Isotonic Nasal Wash (Seawater) in the Treatment and Prevention of Rhinitis in Children. Arch Otolaryngol Head Neck Surg. 2008; 134(1): 67-74.
[9] WHO Guidelines for Pharmacological Management of Pandemic (H1N1) 2009 Influenza and other Influenza Viruses 20 August 2009 
http://www.who.int/csr/resources/publications/swineflu/h1n1 use_antivirals_20090820/en/
[10] Meltzer EO, Hamilos DL, Hadley JA, et al.: Rhinosinusitis: Developing guidance for clinical trials. J Allergy Clin Immunol 2006, 118:S17-61.
[11] Ao, H.; Wang, Q.; Jiang, B.; He, P.: Efficacy and mechanism of nasal irrigation with a hand pump against influenza and non-influenza viral upper respiratory tract infection. J. of Infectious Diseases and Immunity Vol. 3(6), 2011, 96-105.
[12] Medical staffs of Wuhan and Beijing hospitals commented for prevention of COVID-19 in the period of February to April.
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